Michael Sismour

Department of Genetics & Wyss Institute for Biologically
Inspired Engineering, Harvard Medical School, USA

SynBio 2011
Credits: Harvard Medical School

Dr. Michael Sismour received a B.S. in Microbiology and a Ph.D. in Chemistry at the University of Florida while studying nucleic acid chemistry under Dr. Steven Benner. He is credited with developing the first artificial genetic system capable of directing its own replication and coauthoring the first review article on synthetic biology. Dr. Sismour is currently a postdoctoral fellow in the laboratory of Dr. George Church in the Genetics department and the Wyss Institute for Biologically Inspired Engineering at Harvard Medical School.

Currently, his research investigates ultra high-throughput selection and screening methods for the diversity-oriented synthesis and evolution of organisms and functional biopolymers. Towards this end, he has developed a system that combines next-generation DNA sequencing technology with imaging technology to measure kinetics and binding of function biopolymers, allowing robust, time efficient selection of "smart" aptamers and DNAzymes (catalytic DNA molecules).

Additionnal information is available here.